The role of apoe∊ 4 in modulating effects of other risk factors for cognitive decline in elderly persons
MN Haan, L Shemanski, WJ Jagust, TA Manolio… - Jama, 1999 - jamanetwork.com
ContextCognitive decline in elderly persons is often an early predictor of dementia.
Subclinical cardiovascular disease (CVD) and diabetes mellitus may contribute to
substantial decline in cognitive function in the elderly. These risks may be modified by gene-
environment interactions between apolipoprotein E (APOE) genotype and CVD risk factors
or subclinical CVD. ObjectivesTo examine the association between subclinical CVD and
decline in cognitive functioning in the elderly and to examine effect modification by the …
Subclinical cardiovascular disease (CVD) and diabetes mellitus may contribute to
substantial decline in cognitive function in the elderly. These risks may be modified by gene-
environment interactions between apolipoprotein E (APOE) genotype and CVD risk factors
or subclinical CVD. ObjectivesTo examine the association between subclinical CVD and
decline in cognitive functioning in the elderly and to examine effect modification by the …
