Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir
JM Markert, A Malick, DM Coen, RL Martuza - Neurosurgery, 1993 - journals.lww.com
Abstract MALIGNANT GLIOMAS ARE the most common malignant brain tumors and are
almost universally fatal. A genetically engineered herpes simplex virus-1 mutant with
decreased neurovirulence, dlsptk, has been shown to kill human glioma cells in culture and
in animal models. However, intracranial inoculation of dlsptk is limited by fatal encephalitis
at higher doses. Therefore, additional engineered and recombinant herpes simplex mutants
with demonstrated reduced neurovirulence (AraA r 9, AraA r 13, RE6, R3616) were …
almost universally fatal. A genetically engineered herpes simplex virus-1 mutant with
decreased neurovirulence, dlsptk, has been shown to kill human glioma cells in culture and
in animal models. However, intracranial inoculation of dlsptk is limited by fatal encephalitis
at higher doses. Therefore, additional engineered and recombinant herpes simplex mutants
with demonstrated reduced neurovirulence (AraA r 9, AraA r 13, RE6, R3616) were …
