[HTML][HTML] Signaling pathways activated by oncogenic forms of Abl tyrosine kinase
X Zou, K Calame - Journal of Biological Chemistry, 1999 - ASBMB
From the Department of Biochemistry and Molecular Biophysics and Microbiology, Columbia
University College of Physicians and Surgeons, New York, New York 10032 v-Abl, encoded
by the Abelson murine leukemia virus, is a nonreceptor tyrosine kinase with potent
oncogenic activity in mice (for review, see Refs. 1 and 2). A similar human oncoprotein, BCR-
ABL, is critical in the pathogenesis of 95% of chronic myelogenous leukemia (CML) 1 and
10% of acute lymphocytic leukemia (for review, see Refs. 3 and 4). The c-Abl proto …
University College of Physicians and Surgeons, New York, New York 10032 v-Abl, encoded
by the Abelson murine leukemia virus, is a nonreceptor tyrosine kinase with potent
oncogenic activity in mice (for review, see Refs. 1 and 2). A similar human oncoprotein, BCR-
ABL, is critical in the pathogenesis of 95% of chronic myelogenous leukemia (CML) 1 and
10% of acute lymphocytic leukemia (for review, see Refs. 3 and 4). The c-Abl proto …