Immune responses to adenoviruses: viral evasion mechanisms and their implications for the clinic
WSM Wold, K Doronin, K Toth, M Kuppuswamy… - Current opinion in …, 1999 - Elsevier
WSM Wold, K Doronin, K Toth, M Kuppuswamy, DL Lichtenstein, AE Tollefson
Current opinion in immunology, 1999•ElsevierAdenoviruses encode proteins that block responses to interferons, intrinsic cellular
apoptosis, killing by CD8+ cytotoxic T lymphocytes and killing by the death ligands TNF, Fas
ligand and TRAIL. The viral proteins are believed to prolong acute and persistent
adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy
vectors and transplanted cells from the immune system.
apoptosis, killing by CD8+ cytotoxic T lymphocytes and killing by the death ligands TNF, Fas
ligand and TRAIL. The viral proteins are believed to prolong acute and persistent
adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy
vectors and transplanted cells from the immune system.
Adenoviruses encode proteins that block responses to interferons, intrinsic cellular apoptosis, killing by CD8+ cytotoxic T lymphocytes and killing by the death ligands TNF, Fas ligand and TRAIL. The viral proteins are believed to prolong acute and persistent adenovirus infections. The proteins may prove useful in protecting adenovirus gene therapy vectors and transplanted cells from the immune system.
Elsevier
