The expression of the complement C5a anaphylatoxin receptor (C5aR) has traditionally
been thought to be limited to myeloid blood cells, including neutrophils, monocytes,
macrophages, and eosinophils. Immunohistochemistry and ligand-binding studies reported
here demonstrate, however, that C5aR is expressed by parenchymal cells of several solid
organs, including human liver hepatocytes, lung bronchial and alveolar epithelial cells, and
lung vascular smooth muscle and endothelial cells. In addition to C5aR expression in liver …