The superantigen exfoliative toxin induces cutaneous lymphocyte-associated antigen expression in peripheral human T lymphocytes
TM Zollner, ME Munk, T Keller, V Nuber… - Immunology letters, 1996 - Elsevier
Several immune-mediated dermatoses including psoriasis and atopic dermatitis can be
exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from
skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell
receptor variable gene usage has been demonstrated within these lesions. Therefore, the
question arises whether superantigens induce a skin-seeking phenotype within peripheral T
cells. In this study, we investigated the in vitro influence of the Vβ2-selective superantigen …
exacerbated by bacterial infections. Superantigen producing bacteria can be isolated from
skin lesions of these dermatoses. Consistent with superantigen effects, skewed T cell
receptor variable gene usage has been demonstrated within these lesions. Therefore, the
question arises whether superantigens induce a skin-seeking phenotype within peripheral T
cells. In this study, we investigated the in vitro influence of the Vβ2-selective superantigen …