Complex formation between junctin, triadin, calsequestrin, and the ryanodine receptor: proteins of the cardiac junctional sarcoplasmic reticulum membrane
L Zhang, J Kelley, G Schmeisser, YM Kobayashi… - Journal of Biological …, 1997 - ASBMB
Several key proteins have been localized to junctional sarcoplasmic reticulum which are
important for Ca 2+ release. These include the ryanodine receptor, triadin, and
calsequestrin, which may associate into a stable complex at the junctional membrane. We
recently purified and cloned a fourth component of this complex, junctin, which exhibits
homology with triadin and is the major 125 I-calsequestrin-binding protein detected in
cardiac sarcoplasmic reticulum vesicles (Jones, LR, Zhang, L., Sanborn, K., Jorgensen, AO …
important for Ca 2+ release. These include the ryanodine receptor, triadin, and
calsequestrin, which may associate into a stable complex at the junctional membrane. We
recently purified and cloned a fourth component of this complex, junctin, which exhibits
homology with triadin and is the major 125 I-calsequestrin-binding protein detected in
cardiac sarcoplasmic reticulum vesicles (Jones, LR, Zhang, L., Sanborn, K., Jorgensen, AO …
