[HTML][HTML] p130/E2F4 binds to and represses the cdc2 promoter in response to p53
WR Taylor, AH Schönthal, J Galante… - Journal of Biological …, 2001 - ASBMB
p53 represses the transcription ofcdc2 and cyclin B1, causing loss of Cdc2 activity and G 2
arrest. Here we show that the region− 22 to− 2 of the cdc2 promoter called the R box is
required for repression by p53 but not for basal promoter activity. The R box confers p53-
dependent repression on heterologous promoters and binds to p130/E2F4 in response to
overexpression of p53. R box-dependent repression requires p21/waf1, and overexpression
of p21/waf1 also represses the cdc2promoter. These observations suggest that p53 …
arrest. Here we show that the region− 22 to− 2 of the cdc2 promoter called the R box is
required for repression by p53 but not for basal promoter activity. The R box confers p53-
dependent repression on heterologous promoters and binds to p130/E2F4 in response to
overexpression of p53. R box-dependent repression requires p21/waf1, and overexpression
of p21/waf1 also represses the cdc2promoter. These observations suggest that p53 …
