p53 in embryonic development: maintaining a fine balance
J Choi, LA Donehower - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
J Choi, LA Donehower
Cellular and Molecular Life Sciences CMLS, 1999•SpringerIn addition to its role as a tumour suppressor and cell-cycle checkpoint control protein, p53
has been implicated as an important protein in embryonic development. Despite the viability
of most p53 null mice, evidence has accumulated that p53 may regulate differentiation and
the response of embryonic cells to diverse environmental stresses. Moreover, it appears that
maintenance of a fine balance of p53 protein levels within embryonic cells is important for
optimal development. Inappropriate overexpression or underexpression of p53 can lead to …
has been implicated as an important protein in embryonic development. Despite the viability
of most p53 null mice, evidence has accumulated that p53 may regulate differentiation and
the response of embryonic cells to diverse environmental stresses. Moreover, it appears that
maintenance of a fine balance of p53 protein levels within embryonic cells is important for
optimal development. Inappropriate overexpression or underexpression of p53 can lead to …
Abstract
In addition to its role as a tumour suppressor and cell-cycle checkpoint control protein, p53 has been implicated as an important protein in embryonic development. Despite the viability of most p53 null mice, evidence has accumulated that p53 may regulate differentiation and the response of embryonic cells to diverse environmental stresses. Moreover, it appears that maintenance of a fine balance of p53 protein levels within embryonic cells is important for optimal development. Inappropriate overexpression or underexpression of p53 can lead to embryonic lethality or increased risk of malformations. The p53 protein may utilize multiple functional activities in its regulation of developmental processes.
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