[HTML][HTML] In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2
S Lehtonen, A Ora, VM Olkkonen, L Geng… - Journal of Biological …, 2000 - ASBMB
We identified a developmentally regulated gene from mouse kidney whose expression is up-
regulated in metanephrogenic mesenchyme cells when they are induced to differentiate to
epithelial cells during kidney organogenesis. The deduced 70.5-kDa protein, originally
named METS-1 (mesenchyme-to-epithelium transition protein with SH3 domains), has since
been cloned as a CD2-associated protein (CD2AP). CD2AP is strongly expressed in
glomerular podocytes, and the absence of CD2AP in mice results in congenital nephrotic …
regulated in metanephrogenic mesenchyme cells when they are induced to differentiate to
epithelial cells during kidney organogenesis. The deduced 70.5-kDa protein, originally
named METS-1 (mesenchyme-to-epithelium transition protein with SH3 domains), has since
been cloned as a CD2-associated protein (CD2AP). CD2AP is strongly expressed in
glomerular podocytes, and the absence of CD2AP in mice results in congenital nephrotic …