NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic mice
RS Abraham, SB Wilson, NF de Souza Jr… - Human immunology, 1999 - Elsevier
The major histocompatibility complex (MHC) genes play a significant role in the
predisposition to insulin-dependent diabetes mellitus or type 1 diabetes. HLA-DQ8 (DQB1∗
0302, DQA1∗ 0301) genes have been shown to have the highest relative risk for human
type 1 diabetes. To develop a “humanized” mouse model of diabetes, HLA-DQ8 was
transgenically expressed in mice lacking endogenous class II genes. Since non-MHC
background genes of the NOD influence the disease process, Aβo/DQ8 mice were mated …
predisposition to insulin-dependent diabetes mellitus or type 1 diabetes. HLA-DQ8 (DQB1∗
0302, DQA1∗ 0301) genes have been shown to have the highest relative risk for human
type 1 diabetes. To develop a “humanized” mouse model of diabetes, HLA-DQ8 was
transgenically expressed in mice lacking endogenous class II genes. Since non-MHC
background genes of the NOD influence the disease process, Aβo/DQ8 mice were mated …