Casein kinase II phosphorylation of E-cadherin increases E-cadherin/β-catenin interaction and strengthens cell-cell adhesion
H Lickert, A Bauer, R Kemler, J Stappert - Journal of Biological Chemistry, 2000 - ASBMB
β-Catenin, a member of the Armadillo repeat protein family, binds directly to the cytoplasmic
domain of E-cadherin, linking it via α-catenin to the actin cytoskeleton. A 30-amino acid
region within the cytoplasmic domain of E-cadherin, conserved among all classical
cadherins, has been shown to be essential for β-catenin binding. This region harbors
several putative casein kinase II (CKII) and glycogen synthase kinase-3β (GSK-3β)
phosphorylation sites and is highly phosphorylated. Here we report that in vitro this region is …
domain of E-cadherin, linking it via α-catenin to the actin cytoskeleton. A 30-amino acid
region within the cytoplasmic domain of E-cadherin, conserved among all classical
cadherins, has been shown to be essential for β-catenin binding. This region harbors
several putative casein kinase II (CKII) and glycogen synthase kinase-3β (GSK-3β)
phosphorylation sites and is highly phosphorylated. Here we report that in vitro this region is …
