Rho-family GTPases in cadherin-mediated cell—cell adhesion
M Fukata, K Kaibuchi - Nature reviews Molecular cell biology, 2001 - nature.com
M Fukata, K Kaibuchi
Nature reviews Molecular cell biology, 2001•nature.comCell? cell adhesions are rearranged dynamically during tissue development and tumour
metastasis. Recently, Rho-family GTPases, including RhoA, Rac1 and Cdc42, have
emerged as key regulators of cadherin-mediated cell? cell adhesion. Following the
identification and characterization of regulators and effectors of Rho GTPases, signal
transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to
cadherin, are beginning to be clarified.
metastasis. Recently, Rho-family GTPases, including RhoA, Rac1 and Cdc42, have
emerged as key regulators of cadherin-mediated cell? cell adhesion. Following the
identification and characterization of regulators and effectors of Rho GTPases, signal
transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to
cadherin, are beginning to be clarified.
Abstract
Cell?cell adhesions are rearranged dynamically during tissue development and tumour metastasis. Recently, Rho-family GTPases, including RhoA, Rac1 and Cdc42, have emerged as key regulators of cadherin-mediated cell?cell adhesion. Following the identification and characterization of regulators and effectors of Rho GTPases, signal transduction pathways from cadherin to Rho GTPases and, in turn, from Rho GTPases to cadherin, are beginning to be clarified.
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