[HTML][HTML] Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease
H Yoshida, A Watanabe, Y Ihara - Journal of Biological Chemistry, 1998 - ASBMB
Intraneuronal accumulation of paired helical filaments (PHF) is considered to be closely
related to the neuronal loss observed in brains of patients affected with Alzheimer's disease.
The central issue is whether PHF formation itself causes or accelerates the neuronal
perikaryal and neuritic degeneration or whether they are simply the consequence of
preceding degeneration. We sought to address the issue in part by characterizing the PHF-
associated molecules and thus raised a number of monoclonal antibodies to neurofibrillary …
related to the neuronal loss observed in brains of patients affected with Alzheimer's disease.
The central issue is whether PHF formation itself causes or accelerates the neuronal
perikaryal and neuritic degeneration or whether they are simply the consequence of
preceding degeneration. We sought to address the issue in part by characterizing the PHF-
associated molecules and thus raised a number of monoclonal antibodies to neurofibrillary …
