[HTML][HTML] Cleavage of focal adhesion kinase by different proteases during Src-regulated transformation and apoptosis: distinct roles for calpain and caspases
NO Carragher, VJ Fincham, D Riley… - Journal of Biological …, 2001 - ASBMB
Integrin-associated focal adhesion complexes provide the main adhesive links between the
cellular actin cytoskeleton and the surrounding extracellular matrix. In vitro, cells utilize a
complex temporal and spatially regulated mechanism of focal adhesion assembly and
disassembly required for cell migration. Recent studies indicate that members of both
calpain and caspase protease families can promote limited proteolytic cleavage of several
components of focal adhesions leading to disassembly of these complexes. Such …
cellular actin cytoskeleton and the surrounding extracellular matrix. In vitro, cells utilize a
complex temporal and spatially regulated mechanism of focal adhesion assembly and
disassembly required for cell migration. Recent studies indicate that members of both
calpain and caspase protease families can promote limited proteolytic cleavage of several
components of focal adhesions leading to disassembly of these complexes. Such …
