[HTML][HTML] Stem cell factor/c-kit up-regulates cyclin D3 and promotes cell cycle progression via the phosphoinositide 3-kinase/p70 S6 kinase pathway in spermatogonia
LX Feng, N Ravindranath, M Dym - Journal of Biological Chemistry, 2000 - ASBMB
Stem cell factor (SCF)/c-kit plays an important role in the regulation of hematopoiesis,
melanogenesis, and spermatogenesis. In the testis, the SCF/c-kit system is believed to
regulate germ cell proliferation, meiosis, and apoptosis. Studies with type A spermatogonia
in vivo and in vitro have indicated that SCF induces DNA synthesis and proliferation.
However, the signaling pathway for this function of SCF/c-kit has not been elucidated. We
now demonstrate that SCF activates phosphoinositide 3-kinase (PI3-K) and p70 S6 kinase …
melanogenesis, and spermatogenesis. In the testis, the SCF/c-kit system is believed to
regulate germ cell proliferation, meiosis, and apoptosis. Studies with type A spermatogonia
in vivo and in vitro have indicated that SCF induces DNA synthesis and proliferation.
However, the signaling pathway for this function of SCF/c-kit has not been elucidated. We
now demonstrate that SCF activates phosphoinositide 3-kinase (PI3-K) and p70 S6 kinase …
