Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343
S Persad, S Attwell, V Gray, N Mawji, JT Deng… - Journal of Biological …, 2001 - ASBMB
Protein kinase B (PKB/Akt) is a regulator of cell survival and apoptosis. To become fully
activated, PKB/Akt requires phosphorylation at two sites, threonine 308 and serine 473, in a
phoshpatidylinositol (PI) 3-kinase-dependent manner. The kinase responsible for
phosphorylation of threonine 308 is the PI 3-kinase-dependent kinase-1 (PDK-1), whereas
phosphorylation of serine 473 has been suggested to be regulated by PKB/Akt
autophosphorylation in a PDK-1-dependent manner. However, the integrin-linked kinase …
activated, PKB/Akt requires phosphorylation at two sites, threonine 308 and serine 473, in a
phoshpatidylinositol (PI) 3-kinase-dependent manner. The kinase responsible for
phosphorylation of threonine 308 is the PI 3-kinase-dependent kinase-1 (PDK-1), whereas
phosphorylation of serine 473 has been suggested to be regulated by PKB/Akt
autophosphorylation in a PDK-1-dependent manner. However, the integrin-linked kinase …
