Molecular structure of the water channel through aquaporin CHIP. The hourglass model.
JS Jung, GM Preston, BL Smith, WB Guggino… - Journal of Biological …, 1994 - ASBMB
Aquaporin channel-forming integral protein (CHIP) is the first characterized water channel
protein (genome symbol AQP1), but the molecular structure of the aqueous pathway through
CHIP remains undefined. The two halves of CHIP are sequence-related, and each has three
bilayer-spanning domains with the motif asparagine-proline-alanine (NPA) at residues 76-
78 (in cytoplasmic loop B) and 192-194 (in extracellular loop E). The NPA motifs are
oriented 180 degrees to each other, and the second NPA is near cysteine 189, the known …
protein (genome symbol AQP1), but the molecular structure of the aqueous pathway through
CHIP remains undefined. The two halves of CHIP are sequence-related, and each has three
bilayer-spanning domains with the motif asparagine-proline-alanine (NPA) at residues 76-
78 (in cytoplasmic loop B) and 192-194 (in extracellular loop E). The NPA motifs are
oriented 180 degrees to each other, and the second NPA is near cysteine 189, the known …