[HTML][HTML] Substitution of the seat-belt region of the thyroid-stimulating hormone (TSH) β-subunit with the corresponding regions of choriogonadotropin or follitropin …
M Grossmann, MW Szkudlinski, R Wong… - Journal of Biological …, 1997 - ASBMB
The region between the 10th and 12th cysteine (Cys 88-Cys 105 in human thyroid-
stimulating hormone β-subunit (hTSHβ)) of the glycoprotein hormone β-subunits
corresponds to the disulfide-linked seat-belt region. It wraps around the common α-subunit
and has been implicated in regulating specificity between human choriogonadotropin (hCG)
and human follicle-stimulating hormone (hFSH), but determinants of hTSH specificity are
unknown. To characterize the role of this region for hTSH, we constructed hTSH chimeras in …
stimulating hormone β-subunit (hTSHβ)) of the glycoprotein hormone β-subunits
corresponds to the disulfide-linked seat-belt region. It wraps around the common α-subunit
and has been implicated in regulating specificity between human choriogonadotropin (hCG)
and human follicle-stimulating hormone (hFSH), but determinants of hTSH specificity are
unknown. To characterize the role of this region for hTSH, we constructed hTSH chimeras in …
