[HTML][HTML] Epoxygenase pathways of arachidonic acid metabolism
DC Zeldin - Journal of Biological Chemistry, 2001 - ASBMB
Arachidonic acid (AA) 1 is present in vivo esterified to cell membrane glycerophospholipids.
Activation of phospholipases (eg cytosolic phospholipase A2) releases free AA from the
phospholipid (PL) pools and makes it available for oxidative metabolism by several enzyme
systems (Fig. 1). The prostaglandin endoperoxide H synthases (PGHSs) metabolize AA to
PGH2, which serves as the precursor of the prostaglandins, thromboxane and prostacyclin
(1). The lipoxygenases (LOXs) convert AA to labile hydroperoxy intermediates that go on to …
Activation of phospholipases (eg cytosolic phospholipase A2) releases free AA from the
phospholipid (PL) pools and makes it available for oxidative metabolism by several enzyme
systems (Fig. 1). The prostaglandin endoperoxide H synthases (PGHSs) metabolize AA to
PGH2, which serves as the precursor of the prostaglandins, thromboxane and prostacyclin
(1). The lipoxygenases (LOXs) convert AA to labile hydroperoxy intermediates that go on to …