Presenilin 1 regulates pharmacologically distinct γ-secretase activities: implications for the role of presenilin in γ-secretase cleavage
MP Murphy, SN Uljon, PE Fraser, A Fauq… - Journal of Biological …, 2000 - ASBMB
Presenilins (PSs) are polytopic membrane proteins that have been implicated as potential
therapeutic targets in Alzheimer's disease because of their role in regulating the γ-secretase
cleavage that generates the amyloid β protein (Aβ). It is not clear how PSs regulate γ-
secretase cleavage, but there is evidence that PSs could be either essential cofactors in the
γ-secretase cleavage, γ-secretase themselves, or regulators of intracellular trafficking that
indirectly influence γ-secretase cleavage. Using presenilin 1 (PS1) mutants that inhibit Aβ …
therapeutic targets in Alzheimer's disease because of their role in regulating the γ-secretase
cleavage that generates the amyloid β protein (Aβ). It is not clear how PSs regulate γ-
secretase cleavage, but there is evidence that PSs could be either essential cofactors in the
γ-secretase cleavage, γ-secretase themselves, or regulators of intracellular trafficking that
indirectly influence γ-secretase cleavage. Using presenilin 1 (PS1) mutants that inhibit Aβ …
