[HTML][HTML] Two Receptor Systems Are Involved in the Plasma Clearance of Tissue Factor Pathway Inhibitor in Vivo (∗)
M Narita, G Bu, GM Olins, DA Higuchi, J Herz… - Journal of Biological …, 1995 - ASBMB
Tissue factor pathway inhibitor (TFPI) is a potent inhibitor of the blood coagulation factor VIIa-
tissue factor complex, as well as a direct inhibitor of factor Xa. Intravenously administered
TFPI is rapidly cleared from circulation predominantly via liver. We previously reported that
the low density lipoprotein receptor-related protein (LRP), a multifunctional endocytic
receptor, mediates the uptake and degradation of TFPI in hepatoma cells. This process is
inhibited by a 39-kDa receptor-associated protein which binds to LRP and regulates its …
tissue factor complex, as well as a direct inhibitor of factor Xa. Intravenously administered
TFPI is rapidly cleared from circulation predominantly via liver. We previously reported that
the low density lipoprotein receptor-related protein (LRP), a multifunctional endocytic
receptor, mediates the uptake and degradation of TFPI in hepatoma cells. This process is
inhibited by a 39-kDa receptor-associated protein which binds to LRP and regulates its …
