[HTML][HTML] ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999
FL Zhang, L Luo, E Gustafson, J Lachowicz… - Journal of Biological …, 2001 - ASBMB
P2Y receptors are a class of G protein-coupled receptors activated primarily by ATP, UTP,
and UDP. Five mammalian P2Y receptors have been cloned so far including P2Y1, P2Y2,
P2Y4, P2Y6, and P2Y11. P2Y1, P2Y2, and P2Y6 couple to the activation of phospholipase
C, whereas P2Y4 and P2Y11 couple to the activation of both phospholipase C and the
adenylyl cyclase pathways. Additional ADP receptors linked to Gα i have been described but
have not yet been cloned. SP1999 is an orphan G protein-coupled receptor, which is highly …
and UDP. Five mammalian P2Y receptors have been cloned so far including P2Y1, P2Y2,
P2Y4, P2Y6, and P2Y11. P2Y1, P2Y2, and P2Y6 couple to the activation of phospholipase
C, whereas P2Y4 and P2Y11 couple to the activation of both phospholipase C and the
adenylyl cyclase pathways. Additional ADP receptors linked to Gα i have been described but
have not yet been cloned. SP1999 is an orphan G protein-coupled receptor, which is highly …