[HTML][HTML] Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist
N Lenain, M Freund, C Leon, JP Cazenave… - Journal of Thrombosis …, 2003 - Elsevier
Previous studies in experimental models revealed a role for the P2Y 1 platelet ADP receptor
in systemic vascular thromboembolism models. In the present work, we used models of
localized arterial and venous thrombosis to assess the role of the P2Y 1 receptor in these
processes. Arterial thrombosis was induced in one mesenteric arteriole of a mouse using
FeCl 3, while venous thrombosis was studied in a Wessler model adapted to rats. P2Y 1-
deficient mice and mice treated with the P2Y 1 antagonist MRS2179 displayed significantly …
in systemic vascular thromboembolism models. In the present work, we used models of
localized arterial and venous thrombosis to assess the role of the P2Y 1 receptor in these
processes. Arterial thrombosis was induced in one mesenteric arteriole of a mouse using
FeCl 3, while venous thrombosis was studied in a Wessler model adapted to rats. P2Y 1-
deficient mice and mice treated with the P2Y 1 antagonist MRS2179 displayed significantly …