Progress and problems with the use of viral vectors for gene therapy
CE Thomas, A Ehrhardt, MA Kay - Nature Reviews Genetics, 2003 - nature.com
CE Thomas, A Ehrhardt, MA Kay
Nature Reviews Genetics, 2003•nature.comGene therapy has a history of controversy. Encouraging results are starting to emerge from
the clinic, but questions are still being asked about the safety of this new molecular
medicine. With the development of a leukaemia-like syndrome in two of the small number of
patients that have been cured of a disease by gene therapy, it is timely to contemplate how
far this technology has come, and how far it still has to go.
the clinic, but questions are still being asked about the safety of this new molecular
medicine. With the development of a leukaemia-like syndrome in two of the small number of
patients that have been cured of a disease by gene therapy, it is timely to contemplate how
far this technology has come, and how far it still has to go.
Abstract
Gene therapy has a history of controversy. Encouraging results are starting to emerge from the clinic, but questions are still being asked about the safety of this new molecular medicine. With the development of a leukaemia-like syndrome in two of the small number of patients that have been cured of a disease by gene therapy, it is timely to contemplate how far this technology has come, and how far it still has to go.
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