Induction of erosive arthritis in mice after passive transfer of anti-type II collagen antibodies
N Loutis, P Bruckner, A Pataki - Agents and actions, 1988 - Springer
N Loutis, P Bruckner, A Pataki
Agents and actions, 1988•SpringerThe passive transfer of concentrated immunoglobulins or affinity-purified anti-collagen
antibodies from sera of mice with type II collagen-induced arthritis can induce erosive
arthritis in recipient animals. In both cases, the incidence of arthritis was over 60% and the
inflammation persisted for at least two weeks. Radiography revealed bone destruction and
apposition of a newly formed material while histologic examination showed cartilage and
bone degradation, accompanied with synovitis and periarthritis. Inflammatory infiltrates were …
antibodies from sera of mice with type II collagen-induced arthritis can induce erosive
arthritis in recipient animals. In both cases, the incidence of arthritis was over 60% and the
inflammation persisted for at least two weeks. Radiography revealed bone destruction and
apposition of a newly formed material while histologic examination showed cartilage and
bone degradation, accompanied with synovitis and periarthritis. Inflammatory infiltrates were …
Abstract
The passive transfer of concentrated immunoglobulins or affinity-purified anti-collagen antibodies from sera of mice with type II collagen-induced arthritis can induce erosive arthritis in recipient animals. In both cases, the incidence of arthritis was over 60% and the inflammation persisted for at least two weeks. Radiography revealed bone destruction and apposition of a newly formed material while histologic examination showed cartilage and bone degradation, accompanied with synovitis and periarthritis. Inflammatory infiltrates were composed of polymorphonuclear leucocytes and lymphocytes, and were associated with a proliferation of connective tissue cells.
Springer