DNA microarray analysis reveals novel gene expression profiles in collagen-induced arthritis
S Thornton, D Sowders, B Aronow, DP Witte… - Clinical …, 2002 - Elsevier
Global gene expression was analyzed in early and late collagen-induced arthritis (CIA). Of
8734 cDNAs analyzed, 330 were induced and 55 downregulated greater than twofold in
early or late disease. Hierarchical clustering of these 385 cDNAs demonstrated five distinct
expression patterns differentiating early from late disease and correlating with
histopathologic changes in the paw. Of the 385 cDNAs, 185 are known, characterized
genes, the majority of which are not described as playing a role in arthritis. However, several …
8734 cDNAs analyzed, 330 were induced and 55 downregulated greater than twofold in
early or late disease. Hierarchical clustering of these 385 cDNAs demonstrated five distinct
expression patterns differentiating early from late disease and correlating with
histopathologic changes in the paw. Of the 385 cDNAs, 185 are known, characterized
genes, the majority of which are not described as playing a role in arthritis. However, several …