Collagen-induced arthritis in DBA/1 mice: cytokine gene activation following immunization with type II collagen
LM Stasiuk, O Abehsira-Amar, C Fournier - Cellular immunology, 1996 - Elsevier
Immunization of DBA/1 mice with bovine type II collagen (CII) in complete Freund's adjuvant
(CFA) leads to collagen-induced arthritis as evidenced by joint inflammation. In this study,
reverse transcription–polymerase chain reaction (RT–PCR) was used to demonstrate the
activation of genes encoding for IL-2, IFN-γ, and IL-10 in the lymph nodes from both CII-
immunized and control CFA-immunized DBA/1 mice, at Days 10, 40, and 70 after
immunization, in the absence of any IL-5 or IL-13 transcription. By quantitative RT–PCR, the …
(CFA) leads to collagen-induced arthritis as evidenced by joint inflammation. In this study,
reverse transcription–polymerase chain reaction (RT–PCR) was used to demonstrate the
activation of genes encoding for IL-2, IFN-γ, and IL-10 in the lymph nodes from both CII-
immunized and control CFA-immunized DBA/1 mice, at Days 10, 40, and 70 after
immunization, in the absence of any IL-5 or IL-13 transcription. By quantitative RT–PCR, the …