Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 mice
C Plater-Zyberk, AJ Hoogewerf, AEI Proudfoot… - Immunology letters, 1997 - Elsevier
Chemokines are small proteins that selectively activate and recruit leukocytes to sites of
inflammation. Several of them, including the CC chemokines RANTES, MIP-1α, MIP-1β,
MCP-1, and the CXC chemokines IL-8, GRO-α, ENA-78 have been identified in rheumatoid
synovium, implicating a potential role for these molecules in rheumatoid arthritis. We have
investigated the expression patterns of CC chemokine receptors in the joints of mice with
collagen-induced arthritis, a model for human rheumatoid arthritis. In addition, we have …
inflammation. Several of them, including the CC chemokines RANTES, MIP-1α, MIP-1β,
MCP-1, and the CXC chemokines IL-8, GRO-α, ENA-78 have been identified in rheumatoid
synovium, implicating a potential role for these molecules in rheumatoid arthritis. We have
investigated the expression patterns of CC chemokine receptors in the joints of mice with
collagen-induced arthritis, a model for human rheumatoid arthritis. In addition, we have …