Psoriasis and HLA‐Cw6
A Tiilikainen, A Lassus, J Karvonen… - British Journal of …, 1980 - Wiley Online Library
A Tiilikainen, A Lassus, J Karvonen, P Vartiainen, M Julin
British Journal of Dermatology, 1980•Wiley Online LibraryThe prevalence of histocompatibility antigen HLA‐Cw6 was 72.7% in twenty‐two patients
with the guttate form and 45.9% in thirty‐seven patients with the vulgaris form of psoriasis;
the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors
in Finland is highly significant. The previously observed excess of several HLA‐B locus
genes might be secondary to their close linkage with the Cw6 gene. Hereditary factors
appear more important in the guttate than in the vulgaris form of psoriasis.
with the guttate form and 45.9% in thirty‐seven patients with the vulgaris form of psoriasis;
the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors
in Finland is highly significant. The previously observed excess of several HLA‐B locus
genes might be secondary to their close linkage with the Cw6 gene. Hereditary factors
appear more important in the guttate than in the vulgaris form of psoriasis.
Summary
The prevalence of histocompatibility antigen HLA‐Cw6 was 72.7% in twenty‐two patients with the guttate form and 45.9% in thirty‐seven patients with the vulgaris form of psoriasis; the difference between these figures and the prevalence (7.4%) in 462 healthy blood donors in Finland is highly significant. The previously observed excess of several HLA‐B locus genes might be secondary to their close linkage with the Cw6 gene. Hereditary factors appear more important in the guttate than in the vulgaris form of psoriasis.
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