Psoriatic fibroblasts induce hyperproliferation of normal keratinocytes in a skin equivalent model in vitro
PH Saiag, B Coulomb, C Lebreton, E Bell, L Dubertret - Science, 1985 - science.org
PH Saiag, B Coulomb, C Lebreton, E Bell, L Dubertret
Science, 1985•science.orgA skin equivalent model has been used to fabricate tissues with psoriatic and normal cells.
Psoriatic fibroblasts can induce hyperproliferative activity in normal keratinocytes. The
psoriatic epidermis from lesions continues to proliferate at high rates for at least 15 days in
this model, and normal fibroblasts are unable to suppress this hyperproliferation. The
primary defect in psoriatic skin may reside in the dermal fibroblast.
Psoriatic fibroblasts can induce hyperproliferative activity in normal keratinocytes. The
psoriatic epidermis from lesions continues to proliferate at high rates for at least 15 days in
this model, and normal fibroblasts are unable to suppress this hyperproliferation. The
primary defect in psoriatic skin may reside in the dermal fibroblast.
A skin equivalent model has been used to fabricate tissues with psoriatic and normal cells. Psoriatic fibroblasts can induce hyperproliferative activity in normal keratinocytes. The psoriatic epidermis from lesions continues to proliferate at high rates for at least 15 days in this model, and normal fibroblasts are unable to suppress this hyperproliferation. The primary defect in psoriatic skin may reside in the dermal fibroblast.
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