Upregulation of interferon-induced indoleamine 2, 3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1
BD Hissong, GI Byrne, ML Padilla, JM Carlin - Cellular immunology, 1995 - Elsevier
The tryptophan decyclizing enzyme indoleamine 2, 3-dioxygenase (IDO) was induced in
human monocyte-derived macrophages (MDM) treated with human recombinant interferon-
β (IFN-β) or interferon-γ (IFN-γ). Treated cells exhibited dose-dependent increases in IDO
when assayed 48 hr after treatment. Cells exposed to IFN-γ were observed to exhibit
consistently higher peak levels of IDO when compared with cells incubated in the presence
of IFN-β. When IFN-β-treated cells were incubated in the presence of specified amounts of …
human monocyte-derived macrophages (MDM) treated with human recombinant interferon-
β (IFN-β) or interferon-γ (IFN-γ). Treated cells exhibited dose-dependent increases in IDO
when assayed 48 hr after treatment. Cells exposed to IFN-γ were observed to exhibit
consistently higher peak levels of IDO when compared with cells incubated in the presence
of IFN-β. When IFN-β-treated cells were incubated in the presence of specified amounts of …
