Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?
JH Buckner, GT Nepom - Current opinion in rheumatology, 2002 - journals.lww.com
JH Buckner, GT Nepom
Current opinion in rheumatology, 2002•journals.lww.comHuman leukocyte antigen genes associated with rheumatoid arthritis are commonly found in
the unaffected population, implying that causal mechanisms of disease involve interactions
between these genes and other factors. A variety of approaches—genetic, structural, and
immunologic—are used to explore possible molecular interactions that may contribute to
understanding the basis for this disease association. The specific relation between human
leukocyte antigen-DR4 alleles and rheumatoid arthritis remains one of the strongest and …
the unaffected population, implying that causal mechanisms of disease involve interactions
between these genes and other factors. A variety of approaches—genetic, structural, and
immunologic—are used to explore possible molecular interactions that may contribute to
understanding the basis for this disease association. The specific relation between human
leukocyte antigen-DR4 alleles and rheumatoid arthritis remains one of the strongest and …
Abstract
Human leukocyte antigen genes associated with rheumatoid arthritis are commonly found in the unaffected population, implying that causal mechanisms of disease involve interactions between these genes and other factors. A variety of approaches—genetic, structural, and immunologic—are used to explore possible molecular interactions that may contribute to understanding the basis for this disease association. The specific relation between human leukocyte antigen-DR4 alleles and rheumatoid arthritis remains one of the strongest and most thoroughly studied examples of human leukocyte antigen risk genes among human autoimmune disorders.
Lippincott Williams & Wilkins