[HTML][HTML] Inhibition of c-Myc expression sensitizes hepatocytes to tumor necrosis factor-induced apoptosis and necrosis
H Liu, CR Lo, BE Jones, Z Pradhan… - Journal of Biological …, 2000 - ASBMB
The typical proliferative response of hepatocytes to tumor necrosis factor (TNF) can be
converted to a cytotoxic one by transcriptional arrest. Although NF-κB activation is critical for
hepatocyte resistance to TNF toxicity, the contribution of other TNF-inducible transcription
factors remains unknown. To determine the function of c-Myc in hepatocyte sensitivity to
TNF, stable transfectants of the rat hepatocyte cell line RALA255-10G containing sense and
antisense c-myc expression vectors were isolated with increased (S-Myc cells) and …
converted to a cytotoxic one by transcriptional arrest. Although NF-κB activation is critical for
hepatocyte resistance to TNF toxicity, the contribution of other TNF-inducible transcription
factors remains unknown. To determine the function of c-Myc in hepatocyte sensitivity to
TNF, stable transfectants of the rat hepatocyte cell line RALA255-10G containing sense and
antisense c-myc expression vectors were isolated with increased (S-Myc cells) and …