Effect of polycythemia on erythropoietin production in the hypoxic rat
E Necas, J Zivny, J Neuwirt - American Journal of …, 1972 - journals.physiology.org
E Necas, J Zivny, J Neuwirt
American Journal of Physiology-Legacy Content, 1972•journals.physiology.orgMETHODS Male Wistar rats weighing 250-280 g were used. Groups of seven normal or
seven polycythemic rats were exposed to atmospheres with decreased partial pressures of
oxygen for 16 hr, and the erythropoietin activity of plasma collected at the end of the
exposure to the low oxygen pressure was determined. Polycythemia was induced in the rats
by administering intravenously 7.5 ml of packed red blood cells from normal rat donors 3 hr
prior to the exposure to hypoxia. One hour before the exposure to hypoxia, each rat was …
seven polycythemic rats were exposed to atmospheres with decreased partial pressures of
oxygen for 16 hr, and the erythropoietin activity of plasma collected at the end of the
exposure to the low oxygen pressure was determined. Polycythemia was induced in the rats
by administering intravenously 7.5 ml of packed red blood cells from normal rat donors 3 hr
prior to the exposure to hypoxia. One hour before the exposure to hypoxia, each rat was …
METHODS
Male Wistar rats weighing 250-280 g were used. Groups of seven normal or seven polycythemic rats were exposed to atmospheres with decreased partial pressures of oxygen for 16 hr, and the erythropoietin activity of plasma collected at the end of the exposure to the low oxygen pressure was determined.
Polycythemia was induced in the rats by administering intravenously 7.5 ml of packed red blood cells from normal rat donors 3 hr prior to the exposure to hypoxia. One hour before the exposure to hypoxia, each rat was injected intraperitoneally with 70 ml of air. Tissue oxygen
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