Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes
S De Cosmo, S Prudente, F Andreozzi, E Morini… - American Journal of …, 2007 - ajkd.org
Insulin resistance is associated with chronic kidney disease (CKD; defined as an estimated
glomerular filtration rate 60 mL/min/1.73 m2) in patients with type 2 diabetes. 1 The
substitution of glutamine by arginine at amino acid 84 of TRIB3 (the p. Q84R polymorphism)
is associated with insulin resistance. 2 We tested by means of restriction fragment length
polymorphism whether TRIB3 p. Q84R is associated with CKD in a sample of patients with
type 2 diabetes from Italy (529 men, 483 women; age 61.5 10 years). Sex, age, diabetes …
glomerular filtration rate 60 mL/min/1.73 m2) in patients with type 2 diabetes. 1 The
substitution of glutamine by arginine at amino acid 84 of TRIB3 (the p. Q84R polymorphism)
is associated with insulin resistance. 2 We tested by means of restriction fragment length
polymorphism whether TRIB3 p. Q84R is associated with CKD in a sample of patients with
type 2 diabetes from Italy (529 men, 483 women; age 61.5 10 years). Sex, age, diabetes …
