[PDF][PDF] Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
PJ Meier, U Eckhardt, A Schroeder, B Hagenbuch… - …, 1997 - Wiley Online Library
PJ Meier, U Eckhardt, A Schroeder, B Hagenbuch, B Stieger
Hepatology, 1997•Wiley Online LibraryThe Na+‐dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the
Na+‐independent organic anion transporters oatpl (rat) and OATP (human) mediate
sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their
properties indicate that an overall hepatic clearance of albumin‐bound compounds is
mediated by a limited number of multispecific transporters with partially overlapping
substrate specificities.
Na+‐independent organic anion transporters oatpl (rat) and OATP (human) mediate
sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their
properties indicate that an overall hepatic clearance of albumin‐bound compounds is
mediated by a limited number of multispecific transporters with partially overlapping
substrate specificities.
Abstract
The Na+‐dependent bile salt uptake systems Ntcp (rodents) and NTCP (human), and the Na+‐independent organic anion transporters oatpl (rat) and OATP (human) mediate sinusoidal uptake of a variety of amphipathic organic compounds into hepatocytes. Their properties indicate that an overall hepatic clearance of albumin‐bound compounds is mediated by a limited number of multispecific transporters with partially overlapping substrate specificities.
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