Characterization of a suppressor cell line which downgrades experimental autoimmune uveoretinitis in the rat.
RR Caspi, T Kuwabara… - Journal of immunology …, 1988 - journals.aai.org
RR Caspi, T Kuwabara, RB Nussenblatt
Journal of immunology (Baltimore, Md.: 1950), 1988•journals.aai.orgA Ts lymphocyte line was isolated from spleens of rats primed with the retinal soluble Ag
(SAg) in the anterior chamber of the eye. This line could inhibit in vitro SAg-driven
proliferation of uveitogenic Th lymphocytes, in a radioresistant, Ag-independent manner.
Adoptively transferred Ts line cells were found to downgrade experimental autoimmune
uveoretinitis in actively immunized syngeneic recipients. The initial surface phenotype
(OX8+) of the Ts line was unstable in vitro, however, the cells expressed suppressor function …
(SAg) in the anterior chamber of the eye. This line could inhibit in vitro SAg-driven
proliferation of uveitogenic Th lymphocytes, in a radioresistant, Ag-independent manner.
Adoptively transferred Ts line cells were found to downgrade experimental autoimmune
uveoretinitis in actively immunized syngeneic recipients. The initial surface phenotype
(OX8+) of the Ts line was unstable in vitro, however, the cells expressed suppressor function …
Abstract
A Ts lymphocyte line was isolated from spleens of rats primed with the retinal soluble Ag (SAg) in the anterior chamber of the eye. This line could inhibit in vitro SAg-driven proliferation of uveitogenic Th lymphocytes, in a radioresistant, Ag-independent manner. Adoptively transferred Ts line cells were found to downgrade experimental autoimmune uveoretinitis in actively immunized syngeneic recipients. The initial surface phenotype (OX8+) of the Ts line was unstable in vitro, however, the cells expressed suppressor function irrespective of phenotype. The mechanism of suppression did not appear to involve consumption of IL-2 or direct cytolysis of uveitogenic Th lymphocytes, but rather the production of a soluble suppressor factor. These findings may suggest an in vivo role for suppressor lymphocytes, capable of inhibiting primed Th cells, in the regulation of experimental autoimmune uveoretinitis.
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