Dual level inhibition of E2F-1 activity by adeno-associated virus Rep78
RB Batchu, MA Shammas, JY Wang… - Journal of Biological …, 2001 - ASBMB
E2F-1, a major cellular transcription factor, plays a pivotal role in regulating the cell cycle.
The activity of E2F-1 is negatively regulated by its interaction with retinoblastoma protein
(pRB), and disruption of the pRB-E2F-1 complex, a hallmark of cellular transformation by
DNA tumor viruses, leads to cell proliferation. Adeno-associated virus-2 (AAV) is known to
have onco-suppressive properties against DNA tumor viruses. Here we provide, for the first
time, the molecular basis for antioncogenic activity of AAV. Rep78, a major regulatory …
The activity of E2F-1 is negatively regulated by its interaction with retinoblastoma protein
(pRB), and disruption of the pRB-E2F-1 complex, a hallmark of cellular transformation by
DNA tumor viruses, leads to cell proliferation. Adeno-associated virus-2 (AAV) is known to
have onco-suppressive properties against DNA tumor viruses. Here we provide, for the first
time, the molecular basis for antioncogenic activity of AAV. Rep78, a major regulatory …
