Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells
AB Cachelin, JE De Peyer, S Kokubun, H Reuter - Nature, 1983 - nature.com
AB Cachelin, JE De Peyer, S Kokubun, H Reuter
Nature, 1983•nature.comModulation of ion channels is of increasing interest as it is an important step in the regulation
of cellular functions1, 2. We have analysed the effect of 8-bromocyclic AMP on Ca2+
channels in cultured cardiac cells by the patch-clamp method3 and report here that there
was a large increase in the probability of opening of the channels. On the basis of a recently
proposed kinetic reaction scheme4 we suggest that cyclic AMP-dependent phosphorylation
of Ca2+ channels primarily promotes the forward rate constants which lead to the open state …
of cellular functions1, 2. We have analysed the effect of 8-bromocyclic AMP on Ca2+
channels in cultured cardiac cells by the patch-clamp method3 and report here that there
was a large increase in the probability of opening of the channels. On the basis of a recently
proposed kinetic reaction scheme4 we suggest that cyclic AMP-dependent phosphorylation
of Ca2+ channels primarily promotes the forward rate constants which lead to the open state …
Abstract
Modulation of ion channels is of increasing interest as it is an important step in the regulation of cellular functions1,2. We have analysed the effect of 8-bromocyclic AMP on Ca2+ channels in cultured cardiac cells by the patch-clamp method3 and report here that there was a large increase in the probability of opening of the channels. On the basis of a recently proposed kinetic reaction scheme4 we suggest that cyclic AMP-dependent phosphorylation of Ca2+ channels primarily promotes the forward rate constants which lead to the open state of a Ca2+ channel during depolarization.
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