[HTML][HTML] Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development
K Yanagi, T Mizuno, T Tsuyama, S Tada, Y Iida… - Journal of Biological …, 2005 - ASBMB
Cdt1 is an essential component for the assembly of a pre-replicative complex. Cdt1 activity is
inhibited by geminin, which also participates in neural development and embryonic
differentiation in many eukaryotes. Although Cdt1 homologues have been identified in
organisms ranging from yeast to human, geminin homologues had not been described for
Caenorhabditis elegans and fungi. Here, we identify the C. elegans geminin, GMN-1.
Biochemical analysis reveals that GMN-1 associates with C. elegans CDT-1, the Hox protein …
inhibited by geminin, which also participates in neural development and embryonic
differentiation in many eukaryotes. Although Cdt1 homologues have been identified in
organisms ranging from yeast to human, geminin homologues had not been described for
Caenorhabditis elegans and fungi. Here, we identify the C. elegans geminin, GMN-1.
Biochemical analysis reveals that GMN-1 associates with C. elegans CDT-1, the Hox protein …
