Systemic and renal macro-and microcirculatory responses to arginine vasopressin in endotoxic rabbits
M Albert, MR Losser, D Hayon, V Faivre… - Critical care …, 2004 - journals.lww.com
Objective: Arginine vasopressin is being used increasingly to treat vasodilatory hypotension,
although little is known of its effects on regional perfusion. Arginine vasopressin
hemodynamic effects in physiology are mainly mediated through the V1a receptor on blood
vessels. To investigate this further, we studied the effect of arginine vasopressin on systemic
and renal blood flow in anesthetized, ventilated rabbits given either intravenous saline or
endotoxin, and the impact of blocking V1a receptors. Design: Prospective, randomized …
although little is known of its effects on regional perfusion. Arginine vasopressin
hemodynamic effects in physiology are mainly mediated through the V1a receptor on blood
vessels. To investigate this further, we studied the effect of arginine vasopressin on systemic
and renal blood flow in anesthetized, ventilated rabbits given either intravenous saline or
endotoxin, and the impact of blocking V1a receptors. Design: Prospective, randomized …