[HTML][HTML] CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2 and SHP-1
KL Otipoby, KE Draves, EA Clark - Journal of Biological Chemistry, 2001 - ASBMB
Recognition of antigen by the B cell antigen receptor (BCR) determines the subsequent fate
of a B cell and is regulated in part by the involvement of other surface molecules, termed
coreceptors. CD22 is a B cell-restricted coreceptor that gets rapidly tyrosyl-phosphorylated
and recruits various signaling molecules to the membrane following BCR ligation. Although
CD22 contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs), only the two
carboxyl-terminal ITIM tyrosines are required for efficient recruitment of the SHP-1 …
of a B cell and is regulated in part by the involvement of other surface molecules, termed
coreceptors. CD22 is a B cell-restricted coreceptor that gets rapidly tyrosyl-phosphorylated
and recruits various signaling molecules to the membrane following BCR ligation. Although
CD22 contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs), only the two
carboxyl-terminal ITIM tyrosines are required for efficient recruitment of the SHP-1 …
