Inhibition of Na+-taurocholate Co-transporting polypeptide-mediated bile acid transport by cholestatic sulfated progesterone metabolites
S Abu-Hayyeh, P Martinez-Becerra, SHSA Kadir… - Journal of biological …, 2010 - ASBMB
Sulfated progesterone metabolite (P4-S) levels are raised in normal pregnancy and
elevated further in intrahepatic cholestasis of pregnancy (ICP), a bile acid-liver disorder of
pregnancy. ICP can be complicated by preterm labor and intrauterine death. The impact of
P4-S on bile acid uptake was studied using two experimental models of hepatic uptake of
bile acids, namely cultured primary human hepatocytes (PHH) and Na+-taurocholate co-
transporting polypeptide (NTCP)-expressing Xenopus laevis oocytes. Two P4-S …
elevated further in intrahepatic cholestasis of pregnancy (ICP), a bile acid-liver disorder of
pregnancy. ICP can be complicated by preterm labor and intrauterine death. The impact of
P4-S on bile acid uptake was studied using two experimental models of hepatic uptake of
bile acids, namely cultured primary human hepatocytes (PHH) and Na+-taurocholate co-
transporting polypeptide (NTCP)-expressing Xenopus laevis oocytes. Two P4-S …
