Neuregulin-induced expression of the acetylcholine receptor requires endocytosis of ErbB receptors
Neuregulin-induced expression of the acetylcholine receptor (AChR) contributes to high
concentration of the receptor at the neuromuscular junction (NMJ). Neuregulin-1 activates
ErbB tyrosine kinases and subsequently intracellular kinases including Erk that is required
for induced AChR expression. Recent studies demonstrate that ligand-induced
internalization may regulate signaling of various receptor tyrosine kinases. However, the
role of induced ErbB endocytosis in regulating AChR expression was unclear. Here we …
concentration of the receptor at the neuromuscular junction (NMJ). Neuregulin-1 activates
ErbB tyrosine kinases and subsequently intracellular kinases including Erk that is required
for induced AChR expression. Recent studies demonstrate that ligand-induced
internalization may regulate signaling of various receptor tyrosine kinases. However, the
role of induced ErbB endocytosis in regulating AChR expression was unclear. Here we …