Impaired regulation of renal K+ elimination in the sgk1-knockout mouse
DY Huang, P Wulff, H Völkl, J Loffing… - Journal of the …, 2004 - journals.lww.com
Serum-and glucocorticoid-regulated kinase 1 (Sgk1) contributes to Na+ reabsorption in the
aldosterone-sensitive distal nephron. Sgk1-knockout (sgk1−/−) and littermate wild-type mice
(sgk1+/+) were used to test the importance of Sgk1 in renal elimination of K+. Intravenous
application of K+ load under anesthesia increased plasma K+ concentration by 1.3 to 1.4
mM in both sgk1−/−(n= 6) and sgkl+/+(n= 7) mice. However, the increase of absolute and
fractional renal K+ excretion observed in sgk1+/+ was significantly blunted in sgk1 …
aldosterone-sensitive distal nephron. Sgk1-knockout (sgk1−/−) and littermate wild-type mice
(sgk1+/+) were used to test the importance of Sgk1 in renal elimination of K+. Intravenous
application of K+ load under anesthesia increased plasma K+ concentration by 1.3 to 1.4
mM in both sgk1−/−(n= 6) and sgkl+/+(n= 7) mice. However, the increase of absolute and
fractional renal K+ excretion observed in sgk1+/+ was significantly blunted in sgk1 …