[HTML][HTML] Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2
IH Lee, A Dinudom, A Sanchez-Perez, S Kumar… - Journal of biological …, 2007 - ASBMB
The epithelial sodium channel (ENaC) plays an important role in transepithelial Na+
absorption; hence its function is essential for maintaining Na+ and fluid homeostasis and
regulating blood pressure. Insulin is one of the hormones that regulates activity of ENaC. In
this study, we investigated the contribution of two related protein kinases, Akt (also known as
protein kinase B) and the serum-and glucocorticoid-dependent kinase (Sgk), on insulin-
induced ENaC activity in Fisher rat thyroid cells expressing ENaC. Overexpression of Akt1 or …
absorption; hence its function is essential for maintaining Na+ and fluid homeostasis and
regulating blood pressure. Insulin is one of the hormones that regulates activity of ENaC. In
this study, we investigated the contribution of two related protein kinases, Akt (also known as
protein kinase B) and the serum-and glucocorticoid-dependent kinase (Sgk), on insulin-
induced ENaC activity in Fisher rat thyroid cells expressing ENaC. Overexpression of Akt1 or …