[HTML][HTML] A novel pathway of epithelial sodium channel activation involves a serum-and glucocorticoid-inducible kinase consensus motif in the C terminus of the …
A Diakov, C Korbmacher - Journal of Biological Chemistry, 2004 - ASBMB
Aldosterone-induced serum-and glucocorticoid-inducible kinase isoform 1 (SGK1)
contributes to the regulation of the epithelial sodium channel (ENaC), the activity of which is
critical for long term blood pressure control. Aldosterone-induced SGK1 is thought to
enhance ENaC surface expression by phosphorylating Nedd4-2 and thereby preventing
ENaC retrieval and degradation. In outside-out membrane patches of Xenopus laevis
oocytes heterologously expressing ENaC, amiloride-sensitive ENaC currents were …
contributes to the regulation of the epithelial sodium channel (ENaC), the activity of which is
critical for long term blood pressure control. Aldosterone-induced SGK1 is thought to
enhance ENaC surface expression by phosphorylating Nedd4-2 and thereby preventing
ENaC retrieval and degradation. In outside-out membrane patches of Xenopus laevis
oocytes heterologously expressing ENaC, amiloride-sensitive ENaC currents were …