Novel Association of theInterleukin 2-Interleukin 21Region With Inflammatory Bowel Disease
Official journal of the American College of Gastroenterology| ACG, 2009•journals.lww.com
OBJECTIVES: Genome-wide association studies have reported the role of the interleukin
(IL) 2-IL21chromosomal region at 4q27 in several autoimmune conditions. Mice deficient in
IL-2 develop a disease with clinical and histological similarity to ulcerative colitis (UC) in
humans. Modest evidence of linkage with UC was tentatively proposed for theIL2gene more
than a decade ago. Therefore, we decide to investigate the association of polymorphisms in
the IL-2 axis (IL2, IL2RA, andIL2RBgenes) with inflammatory bowel diseases (IBDs) …
(IL) 2-IL21chromosomal region at 4q27 in several autoimmune conditions. Mice deficient in
IL-2 develop a disease with clinical and histological similarity to ulcerative colitis (UC) in
humans. Modest evidence of linkage with UC was tentatively proposed for theIL2gene more
than a decade ago. Therefore, we decide to investigate the association of polymorphisms in
the IL-2 axis (IL2, IL2RA, andIL2RBgenes) with inflammatory bowel diseases (IBDs) …
Abstract
OBJECTIVES:
Genome-wide association studies have reported the role of the interleukin (IL) 2-IL21chromosomal region at 4q27 in several autoimmune conditions. Mice deficient in IL-2 develop a disease with clinical and histological similarity to ulcerative colitis (UC) in humans. Modest evidence of linkage with UC was tentatively proposed for theIL2gene more than a decade ago. Therefore, we decide to investigate the association of polymorphisms in the IL-2 axis (IL2, IL2RA, andIL2RBgenes) with inflammatory bowel diseases (IBDs).
METHODS:
Seven hundred and twenty-eight white Spanish unrelated IBD patients (356 Crohn's disease (CD) and 372 UC) and 549 ethnically matched controls were included in a case-control study. In addition, a Spanish replication cohort with 562 CD and 430 UC patients and 1,310 controls were analyzed. Eight single-nucleotide polymorphisms previously associated with different autoimmune diseases were analyzed using TaqMan chemistry.
RESULTS:
Lippincott Williams & Wilkins