FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus
RM Drenan, X Liu, PG Bertram, XFS Zheng - Journal of Biological …, 2004 - ASBMB
FKBP12-rapamycin-associated protein (FRAP) or mammalian target of rapamycin (mTOR)
and its effector proteins form a critical signaling pathway that regulates eukaryotic cell
growth and proliferation. Although the protein components in this pathway have begun to be
identified, little is known about their subcellular localization or the physiological significance
of their localization. By immunofluorescence, we find that both endogenous and
recombinant FRAP/mTOR proteins show localization predominantly in the endoplasmic …
and its effector proteins form a critical signaling pathway that regulates eukaryotic cell
growth and proliferation. Although the protein components in this pathway have begun to be
identified, little is known about their subcellular localization or the physiological significance
of their localization. By immunofluorescence, we find that both endogenous and
recombinant FRAP/mTOR proteins show localization predominantly in the endoplasmic …
